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218773

Caspase-8 Inhibitor I, Cell-Permeable

Name: Caspase-8 Inhibitor I, Cell-Permeable
Brand: MM

The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.

Synonim(y):

Caspase-8 Inhibitor I, Cell-Permeable, Granzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₉₅H₁₆₂N₂₀O₂₆

Masa cząsteczkowa:

2000.42

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Storage condition:

OK to freeze

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Właściwości

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Opis

General description

A potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.

Potent, cell-permeable and reversible inhibitor of caspase-8 and Granzyme B.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	218759	400011	218767
Sigma-Aldrich 218773 Caspase-8 Inhibitor I, Cell-Permeable	Sigma-Aldrich 218759 Caspase-8 Inhibitor II	Sigma-Aldrich 400011 Caspase-1 Inhibitor I, Cell-Permeable	Sigma-Aldrich 218767 Inhibitor kaspazy-6 II, przepuszczalny dla komórek
description The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.	description The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.	description The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.	description The Caspase-6 Inhibitor II, Cell-Permeable controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.
assay ≥95% (HPLC)	assay -	assay ≥97% (HPLC)	assay ≥97% (HPLC)
form lyophilized solid	form powder	form solid	form lyophilized solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition OK to freeze	storage condition desiccated, OK to freeze	storage condition OK to freeze	storage condition OK to freeze, desiccated (hygroscopic)

Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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