309795

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem^®

• Synonim(y): DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
• Wzór empiryczny (zapis Hilla): C₁₆H₈N₂O₆S₄ · 2Na
• Numer CAS: 53005-05-3
• Masa cząsteczkowa: 498.48
• MDL number: MFCD00065493
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥85% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated, protect from light

Właściwości

• Nazwa produktu: DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
• Quality Segment: 100
• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: yellow
• solubility: water: 0.5%
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [S](=O)(=O)(O)c1c(ccc(c1)N=C=S)\C=C\c2c(cc(cc2)N=C=S)[S](=O)(=O)O
• InChI: 1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
• InChI key: YSCNMFDFYJUPEF-OWOJBTEDSA-N

Opis

General description

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^- uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has antiulcerous activity.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cl- uptake

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Other Notes

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable