324813

Soluble Epoxide Hydrolase Inhibitor, NCND

The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.

• Synonim(y): Soluble Epoxide Hydrolase Inhibitor, NCND, CDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
• Wzór empiryczny (zapis Hilla): C₁₉H₃₈N₂O
• Numer CAS: 402939-18-8
• Masa cząsteczkowa: 310.52
• MDL number: MFCD01344729
• UNSPSC Code: 12352202
• NACRES: NA.54
• Assay: ≥95% (TLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 100
• assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: dichloromethane: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N(C1CCCCC1)C(=O)NCCCCCCCCCCCC
• InChI: 1S/C19H38N2O/c1-2-3-4-5-6-7-8-9-10-14-17-20-19(22)21-18-15-12-11-13-16-18/h18H,2-17H2,1H3,(H2,20,21,22)
• InChI key: POEWFBSYPFIYSK-UHFFFAOYSA-N

Opis

General description

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC₅₀ = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.

A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC₅₀ = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Soluble epoxide hydrolase

Product competes with ATP.

Reversible: no

Target IC₅₀: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA100, 1558.
Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.
Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.
Imig, J.D., et al. 2002. Hypertension39, 690.
Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.
Yu, Z., et al. 2000. Circ. Res.87, 992.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable