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344580

FtsZ Polymer Stabilizer, PC190723

Name: FtsZ Polymer Stabilizer, PC190723
Brand: MM

Synonim(y):

FtsZ Polymer Stabilizer, PC190723, 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₄H₈ClF₂N₃O₂S

Masa cząsteczkowa:

355.75

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥97% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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Właściwości

assay

≥97% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

tan

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Opis

General description

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 μg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC₅₀ = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
FtsZ

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Elsen, N. L., et al. 2012. J. Am. Chem. Soc.134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem.285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem.75, 7946.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	448106	361553	475864
Sigma-Aldrich 344580 FtsZ Polymer Stabilizer, PC190723	Sigma-Aldrich 448106 Inhibitor kinazy metylowej VI, SGX523	Sigma-Aldrich 361553 Inhibitor GSK-3β XI	Sigma-Aldrich 475864 MK-2 Inhibitor III
description -	description The Met Kinase Inhibitor VI, SGX523, also referenced under CAS 1022150-57-7, controls the biological activity of Met Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The GSK-3β Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
form powder	form powder	form solid	form solid
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition protect from light, OK to freeze	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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