382148

Histone Deacetylase Inhibitor II

The Histone Deacetylase Inhibitor II, also referenced under CAS 174664-65-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonim(y): Histone Deacetylase Inhibitor II, CBHA, m-Carboxycinnamic Acid bis-Hydroxamide
• Wzór empiryczny (zapis Hilla): C₁₀H₁₀N₂O₄
• Numer CAS: 174664-65-4
• Masa cząsteczkowa: 222.20
• MDL number: MFCD03453553
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N(O)C(=O)c1cc(ccc1)\C=C\C(=O)NO
• InChI: 1S/C10H10N2O4/c13-9(11-15)5-4-7-2-1-3-8(6-7)10(14)12-16/h1-6,15-16H,(H,11,13)(H,12,14)/b5-4+
• InChI key: OYKBQNOPCSXWBL-SNAWJCMRSA-N

Opis

General description

A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma cells, which can be blocked by Caspase Inhibitor Z-VAD-FMK (Cat. No. 627610).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
HDAC

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Coffey, D.C., et al. 2001. Cancer Res.61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol.35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst.92, 1210.
Glick, R.D., et al. 1999. Cancer Res.59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.

Legal Information

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable