401477

IκB Kinase Inhibitor Peptide, Cell-Permeable

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonim(y): IκB Kinase Inhibitor Peptide, Cell-Permeable, Ac- AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂, Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
• Wzór empiryczny (zapis Hilla): C₁₃₈H₂₂₉N₃₇O₄₅S
• Masa cząsteczkowa: 3158.58
• NACRES: NA.77
• UNSPSC Code: 12352202
• Assay: ≥95% (HPLC)
• Form: lyophilized
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• solubility: PBS, pH 7.4: 1 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Opis

General description

A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.

Biochem/physiol Actions

Cell permeable: no

Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂

Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable