Osteocalcin, Human, with product number O5761, is carboxylated.
499050
Osteocalcin, Bovine Bone
Synonim(y):
Osteocalcin, Bovine Bone, Bone-Gla-Protein, BGP
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
100 μg | Przewidywany termin wysyłki12 listopada 2026zKuehne + Nagel Sp. z o.o. | 2200,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C263H372N66O82S2
Masa cząsteczkowa:
5834.29
NACRES:
NA.42
UNSPSC Code:
12352202
Form:
liquid
Assay:
≥98% (SDS-PAGE)
2200,00 zł
Przewidywany termin wysyłki12 listopada 2026Szczegóły
Pomoc techniczna
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Pozwól nam pomócassay
≥98% (SDS-PAGE)
Quality Segment
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
pI
4.0 - 4.5
shipped in
wet ice
storage temp.
−20°C
General description
Single chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid.
Physical form
In 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Carter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
Watson, K.E., et al. 1994. J. Clin. Invest.93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res.5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem.264, 6972.
Watson, K.E., et al. 1994. J. Clin. Invest.93, 2106.
Tracy, R.P., et al. 1990. J. Bone Min. Res.5, 451.
Gendreau, M.A., et al. 1989. J. Biol. Chem.264, 6972.
H-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Ta pozycja | |||
|---|---|---|---|
| description - | description - | description serum, from rabbit | description clone 4C5, from mouse |
| assay ≥98% (SDS-PAGE) | assay ~95% (affinity purified, SDS-PAGE) | assay - | assay - |
| form liquid | form liquid | form - | form - |
| shipped in wet ice | shipped in dry ice | shipped in wet ice | shipped in ambient |
| storage condition avoid repeated freeze/thaw cycles, OK to freeze | storage condition - | storage condition - | storage condition - |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Klasa składowania
10 - Combustible liquids
Co się dzieje?
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Is the product O5761 - Osteocalcin Human uncarboxylated or decarboxylated?
1 answer-
Helpful?
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Is the Osteocalcin, Bovine Bone #499050, uncarboxylated or decarboxylated?
1 answer-
Osteocalcin, bovine (499050) undergoes carboxylation. A vitamin K dependent carboxylase is responsible for post-translational modification, resulting in the production of three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein consists of 49 amino acids and features a single intrachain disulfide bond connecting Cys23 to Cys29. Osteocalcin is derived from bovine bone.
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