These products are tested and released from different facilities and are of different historical brands. The 567735 is a Calbiochem product that is tested for solubility at 1 mg/mL in a 2:1 mixture of chloroform and methanol. The S4257 is a SigmaAldrich brand item tested for solubility in the same solvent, but at a higher rate. The specification range is 9.8 - 10/2 mg/mL. It is quite likely that the 567735 product option is also soluble at 10 mg/mL. However, the solubility of this product has only been tested at a concentration of 1 mg/mL.
567735
Sphingosylphosphoryl-choline
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.
Synonim(y):
Sphingosylphosphoryl-choline, SPC, lyso-Sphingomyelin
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C23H49N2O5P
Numer CAS:
Masa cząsteczkowa:
464.62
UNSPSC Code:
12352211
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated
Informacje o cenach i dostępności nie są obecnie dostępne.
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Pozwól nam pomócQuality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
chloroform/methanol (2:1): 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[P](=O)([O-])(OC[C@H](N)[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C
InChI
1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
InChI key
JLVSPVFPBBFMBE-HXSWCURESA-N
General description
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
Biochem/physiol Actions
Cell permeable: no
Primary Target
A potent mitogen
A potent mitogen
Product does not compete with ATP.
Reversible: no
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res.669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Dettbarn, C., et al. 1995. Brain Res.669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Ta pozycja | |||
|---|---|---|---|
| description SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. | description ≥98%, powder | description Avanti Research™ - A Croda Brand | description ≥98.0% (TLC) |
| assay ≥98% (TLC) | assay ≥98% | assay >99% (TLC) | assay ≥98.0% (TLC) |
| form solid | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename Avanti Research™ - A Croda Brand | manufacturer/tradename - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility chloroform/methanol (2:1): 1 mg/mL | solubility chloroform/methanol (2:1): complete 10 mg/ml, clear to slightly hazy, colorless to light yellow | solubility - | solubility - |
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Klasa składowania
11 - Combustible Solids
WGK
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Why does SPC(567735) has a solubility 1 mg/mal AND SPC(S4257) has a solubility ~ 10 mg/mL ?
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