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616453

TGF-β RI Kinase Inhibitor III

Name: TGF-β RI Kinase Inhibitor III
Brand: MM

The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonim(y):

TGF-β RI Kinase Inhibitor III, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₀H₂₁N₃O₂ · xHCl

Numer CAS:

356559-13-2

Masa cząsteczkowa:

335.40 (free base basis)

MDL number:

MFCD08276927

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

Informacje o cenach i dostępności nie są obecnie dostępne.

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Właściwości

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

light yellow

solubility

DMSO: 20 mg/mL, water: 3 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Cl.[nH]1c(nc(c1c3cc4c(cc3)OCO4)c2nc(ccc2)C)C(C)(C)C

InChI

1S/C20H21N3O2.ClH/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;/h5-10H,11H2,1-4H3,(H,22,23);1H

InChI key

BTUOOXPZOVNPMF-UHFFFAOYSA-N

Opis

General description

A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC₅₀ = 129 nM), 5 ( IC₅₀ = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC₅₀ = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Activin receptor-like kinase 4, 5, 7

Product competes with ATP.

Reversible: yes

Target IC₅₀: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Ta pozycja	616452	616454	SAB4502960
Sigma-Aldrich 616453 TGF-β RI Kinase Inhibitor III	Sigma-Aldrich 616452 TGF-β RI Kinase Inhibitor II	Sigma-Aldrich 616454 TGF-β RI Kinase Inhibitor IV	Sigma-Aldrich SAB4502960 Anti-TGF β Receptor II antibody produced in rabbit
description The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).	description TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).	description affinity isolated antibody
form solid	form solid	form solid	form buffered aqueous solution
assay ≥97% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay -
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility water: 3 mg/mL, DMSO: 20 mg/mL	solubility methanol: 5 mg/mL, DMSO: 5 mg/mL	solubility DMSO: 20 mg/mL	solubility -

Klasa składowania

11 - Combustible Solids

WGK

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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