AB2202
Anti-PER2 Antibody
serum, Chemicon®
Synonim(y):
Anti-FASPS, Anty-FASPS1
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Wybierz wielkość
100 μL
2050,00 zł
Informacje o tej pozycji
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Przejdź do
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Pozwól nam pomócpochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
serum
rodzaj przeciwciała
primary antibodies
klon
polyclonal
reaktywność gatunkowa
mouse, rat
producent / nazwa handlowa
Chemicon®
metody
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
mouse ... Per2(18627)
1 of 4
Ta pozycja | AB5428P | AB2201 | WH0008864M1 |
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source mouse |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form serum | antibody form affinity purified immunoglobulin | antibody form serum | antibody form purified immunoglobulin |
| shipped in wet ice | shipped in dry ice | shipped in wet ice | shipped in dry ice |
| technique(s) western blot: suitable | technique(s) ELISA: suitable, western blot: suitable | technique(s) western blot: suitable | technique(s) immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL |
| Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per1(18626) | Gene Information human ... PER2(8864) |
Opis ogólny
Approx. 136 kDa Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
Immunogen
Synthetic peptide.
Zastosowanie
Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep
Circadian Rhythm & Sleep
Western Blot Analysis:
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Działania biochem./fizjol.
Cat. # AB2202 will recognize the N-terminus of PER2.
Reactivity with other species has not been determined.
Postać fizyczna
Serum with 0.05% NaN3
Uwaga dotycząca przygotowania
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Komentarz do analizy
Control
C2C12 tissue lysate.
C2C12 tissue lysate.
Routinely evaluated by western blot on C2C12 lysate.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Tomoko Yoshikawa et al.
eNeuro, 8(5) (2021-08-14)
Biological neural networks operate at several levels of granularity, from the individual neuron to local neural circuits to networks of thousands of cells. The daily oscillation of the brain's master clock in the suprachiasmatic nucleus (SCN) rests on a yet
Youli Yao et al.
Frontiers in physiology, 11, 294-294 (2020-05-12)
Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings
Jennifer Gile et al.
Current pharmaceutical design, 26(34), 4330-4337 (2020-04-16)
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B
G Leach et al.
Neuroscience, 234, 31-39 (2013-01-15)
Seasonal affective disorder (SAD) is a major depressive disorder that recurs in the fall and winter when day-length gets short. It is well accepted that day-length is encoded by the principal circadian clock located in the suprachiasmatic nucleus (SCN), but
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
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