AB2286

Anti-Beta (β)-Amyloid antibody

CHEMICON^®, rabbit polyclonal

• Synonim(y): Amyloid Fibrils, Amyloid Fibrils OC
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• Clone: polyclonal
• Species reactivity: human
• Application: DB, ELISA, ICC, IHC, IP, WB
• Citations: 86

Właściwości

• Nazwa produktu: Anti-Amyloid Fibrils OC Antibody, serum, Chemicon^®
• biological source: rabbit
• Quality Segment: 100
• antibody form: serum
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human
• species reactivity (predicted by homology): rat, mouse
• manufacturer/tradename: Chemicon^®
• technique(s): ELISA: suitable, dot blot: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
• isotype: IgG
• NCBI accession no.: NM_000484.2, NM_201413.1, NM_201414.1
• UniProt accession no.: P05067
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... APP(351) ; mouse ... App(11820)

Opis

General description

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. In disease state oligomerization, extensive amyloid oligomerization creates plaques in neural tissue that correlates with Alzheimer’s symptomology.

Immunogen

Fibrils prepared from human Aß42 peptide.

Application

Anti-Amyloid Fibrils OC Antibody is an antibody against Amyloid Fibrils OC for use in IP, IC, IH, ELISA, WB, DB.

Dot Blot Analysis: 1:1,000 dilution of this antibody detected Amyloid fibrils in monomers, oligos, and fibrils.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Biochem/physiol Actions

This antibody recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. It may also show weak reactivity against Aβ monomers while AB2287 does not.

Physical form

Unpurified

Unpurified rabbit polyclonal antibody serum containing 0.05% sodium azide.

Preparation Note

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
Alzheimer′s Brain tissue

Evaluated by Dot Blot in monomers, oligos, and fibrils.

Dot Blot Analysis: 1:1,000 dilution of this antibody detected Amyloid fibrils in monomers, oligos, and fibrils.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 1