AG968

β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human

• UNSPSC Code: 12352202
• NACRES: NA.41
• eCl@ss: 32160405
• Form: (Clear dry film)
• Assay: >97.0%
• Biological source: human

Właściwości

• biological source: human
• Quality Segment: 100
• assay: >97.0%
• form: (Clear dry film)
• manufacturer/tradename: Chemicon^®
• NCBI accession no.: NM_000484.2, NM_201413.1, NM_201414.1
• UniProt accession no.: P05067
• Gene Information: human ... APP(351)

Opis

General description

β Amyloid 1-42 is a derivative of integral membrane-bound amyloid precursor protein. It is the most important alloform of the Alzheimer′s peptide.

Application

β Amyloid 1-42, aβ, ultra-pure, HFIP, recombinant human has been used:

• to study its effect on the activity of mitochondrial BKCa (mitoBKCa) channels in human astrocytoma cells through patch-clamp technique
• to study its effect on alteration in protein levels of dystrophic neurites (DNs) forming proteins in mouse neuroblastoma cells
• to induce Alzheimer′s disease in a rat model for experimental studies

Biochem/physiol Actions

β Amyloid 1-42 causes neurotoxicity and is implicated in the pathogenesis of Alzheimer′s disease (AD). β Amyloid (βA) acts as a ligand for several receptors and other molecules involved in complex trafficking pathways in tissues and blood-brain barriers. βA along with amylin elevates cyclic adenosine monophosphate (cAMP) and Ca²⁺ in turn activates multiple signaling pathway mediators like mitogen-activated protein kinase (MAPK), protein kinase A/B, and cFOS. It acts as the main source of AD-associated neuroinflammation.

Preparation Note

Clear dry film. Resuspend in 1% NH4OH at a concentration of 1 mg/mL. Sonicate for 30 seconds to 1 minute after it has gone into solution. To bring into your solution: After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring to 1x buffer.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 13 - Non Combustible Solids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable