This product may be reconstituted in water to a concentration of 0.1-1.0 mg/mL, do not vortex. For long-term storage, we recommend that the stock solution be further diluted in a buffer containing 0.1% BSA or a similar carrier protein. Store in working aliquots at -20°C to -80°C, and avoid repeated freeze/thaw cycles.
GF168
BMP-6 Protein, Human Recombinant
The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.
Synonim(y):
Bone Morphogenetic Protein 6, BMP6, VRR-1, VG-1-related protein
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
10 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1670,00 zł |
Informacje o tej pozycji
UNSPSC Code:
12352202
NACRES:
NA.77
eCl@ss:
32160405
Assay:
>95% (SDS-PAGE and HPLC)
1670,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócGeneral description
Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Product Source: HEK293 Cells
Application
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Biochem/physiol Actions
Cross Reactivty
None
None
Physical form
Product is filtered through a 0.2 micron filter before lyophilization.
Preparation Note
Store at -20°C for up to 6 months from date of receipt.
Analysis Note
Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Ta pozycja | |||
|---|---|---|---|
| description The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily. | description recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture | description The Human Bone morphogenetic protein 2 (or BMP-2 protein) is a member of the BMP protein subgroup of the TGFβ superfamily. | description BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture |
| assay >95% (SDS-PAGE and HPLC) | assay ≥95% (SDS-PAGE), ≥95% (HPLC) | assay >98% (SDS-PAGE and HPLC) | assay - |
| shipped in dry ice | shipped in wet ice | shipped in dry ice | shipped in - |
| storage temp. -10 to -25°C | storage temp. −20°C | storage temp. -10 to -25°C | storage temp. −20°C |
| impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <0.1 EU/μg endotoxin, tested | impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <1 EU/μg Endotoxin level |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
Klasa składowania
11 - Combustible Solids
WGK
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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