SCC199

HGT-1 Human Gastric Cancer Cell Line

• UNSPSC Code: 41106514
• NACRES: NA.45
• eCl@ss: 32011203
• Technique(s): cell culture | mammalian: suitable

Właściwości

• description: Cell line type: Cancer Cells
• technique(s): cell culture | mammalian: suitable

Opis

General description

Gastric adenocarcinoma is the most common type of gastric cancer, representing 95% of malignancies that originate in the stomach (1). The incidence of gastric adenocarcinoma is especially high in Central and Eastern Asia and areas of Eastern Europe and South America, comprising a significant global health burden (1). Robust models of gastric cancer that reflect the most prevalent form of this disease are therefore highly valuable.

References:
1. Nat Rev Dis Primers 2017; 3: 17036.
2. Cancer Res 1982; 42(4): 1541-1548.

The HGT-1 human gastric cancer cell line is derived from a poorly-differentiated adenocarcinoma and is well-established as a model for studies of gastric cancer and mechanisms of gastric secretion. HGT-1 cells are tumorigenic in nude mice and have a hyperdiploid karyotype (2). HGT-1 cells do not secrete mucus, yet maintain expression of functional histamine H2 receptors also found in normal acid-secreting parietal cells (2).

Source:
The HGT-1 cell line was established from a primary tumor of a 60-year-old male patient (2).

Application

This product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.

Subject to local law, this product is intended to be sold for internal in vitro research use only. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. For additional questions, please contact licensing@milliporesigma.com.

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Analysis Note

• Each vial contains >=1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• WGK: WGK 2
• Temperatura zapłonu (°F): does not flash
• Temperatura zapłonu (°C): does not flash