Product 94581-1EA has 1 gram in the vial, and the enzymatic activity range for this product is ≥ 1500.0 U/VIAL. Each lot is different in the resulting amount per vial; please refer to the Certificate of Analysis for your lot or for lots in inventory.
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94581
Hirudin recombinant from yeast
lyophilized powder, white, >1500 U/vial
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 ea | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 6160,00 zł |
Informacje o tej pozycji
6160,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócQuality Segment
biological source
synthetic, yeast (Pichia pastoris)
form
lyophilized powder
specific activity
>1500 U/vial
mol wt
Mr ~6963.5
color
white
solubility
0.1 M Tris, 0.2 M NaCl, pH 8.4: 1 vial/mL, clear, colorless
storage temp.
−20°C
Application
Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.
Biochem/physiol Actions
Recombinant hirudin appears to be antigenic. Independent studies have found that 50-70% of patients treated for several days with recombinant hirudin develop at least one hirudin antibody isotype. The antibodies reduce the anticoagulant effect of hirudin, but prolong its plasma half-life by reducing renal filtration.
The anticoagulant, hirudin, is the most potent natural inhibitor of both soluble and clot-bound thrombin. It binds thrombin with high affinity, covering more than 20% of its surface area and occluding both the active site and exosite I (fibrinogen and PAR recognition site). Hirudin blocks thrombus growth and platelet activation. It is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration.
Other Notes
1 U corresponds to 1 ATU (antithrombin unit; 1 ATU is defined as the amount of inhibitor that neutralizes 1 NIH unit of thrombin).
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Ta pozycja | |||
|---|---|---|---|
| description lyophilized powder, white, >1500 U/vial | description recombinant, expressed in unspecified host, ≥7,000 ATU/mg protein (ATU = antithrombin units) | description dry powder, pkg of 100 g | description ≥97% (HPLC) |
| biological source yeast (Pichia pastoris), synthetic | biological source - | biological source yeast | biological source - |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 200 |
| form lyophilized powder | form powder | form dry powder | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. room temp | storage temp. −20°C |
| solubility 0.1 M Tris, 0.2 M NaCl, pH 8.4: 1 vial/mL, clear, colorless | solubility water: soluble, pyridine: soluble | solubility water: soluble | solubility - |
| color white | color - | color yellowish to brown | color - |
Klasa składowania
11 - Combustible Solids
WGK
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
PPE (środki ochrony indywidualnej)
Eyeshields, Gloves, type N95 (US)
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How many mg does this product contain or what is the specific activity (range for batched)?
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