This product is intended for research use only and not suitable for human or veterinary use. This material is not tested for in vivo or in vitro applications. However, there are available publications referencing this compound being used successfully in animal models. Please see the link below to review an example of one such paper:
https://www.sciencedirect.com/science/article/pii/S2211124719300671?via%3Dihub
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A5602
AMD3100 octahydrochloride hydrate
≥97% (NMR), solid, CXCR4 antagonist
Synonim(y):
1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride, JM3100, Plerixafor, SID791
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 955,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C28H54N8 · 8HCl · xH2O
Numer CAS:
Masa cząsteczkowa:
794.47 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
desiccated
955,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
AMD3100 octahydrochloride hydrate, ≥97% (NMR), solid
Quality Segment
assay
≥97% (NMR)
form
solid
storage condition
desiccated
solubility
H2O: ≥10 mg/mL, clear
originator
Sanofi Aventis
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2
InChI
1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2
InChI key
GKFHDCZYJHUPEN-UHFFFAOYSA-N
Application
AMD3100 is a highly specific chemokine receptor CXCR4 antagonist. AMD3100 has been used in a study to determine the blockade of CXCR4 in oral squamous cell carcinoma and inhibition of lymph node metastases.
Biochem/physiol Actions
AMD3100 is a highly specific chemokine receptor CXCR4 antagonist.
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Ta pozycja | |||
|---|---|---|---|
| description ≥97% (NMR), solid | description United States Pharmacopeia (USP) Reference Standard | description InSolution, ≥98%, 50 mM aqueous solution, CXCR4 antagonist I | description The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications. |
| form solid | form - | form liquid | form solid |
| assay ≥97% (NMR) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. - | storage temp. −70°C | storage temp. 2-8°C |
| solubility H2O: ≥10 mg/mL, clear | solubility - | solubility - | solubility water: 10 mg/mL |
| storage condition desiccated | storage condition - | storage condition avoid repeated freeze/thaw cycles, OK to freeze, protect from light | storage condition OK to freeze, desiccated (hygroscopic), protect from light |
Klasa składowania
11 - Combustible Solids
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
PPE (środki ochrony indywidualnej)
Eyeshields, Gloves, type N95 (US)
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is this pharmaceutical grade for use in vivo? cat A5602-5mg AMD3100
1 answer-
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Can solutions of Product A5602, AMD3100 octahydrochloride hydrate, be stored?
1 answer-
Sigma-Aldrich has not evaluated the solution stability of A5602. If no information on the solution stability is found from a literature search, we would recommend that that you prepare solutions fresh.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What biological effects has been reported for Product A5602, AMD3100 octahydrochloride hydrate?
1 answer-
This is a highly specific chemokine receptor CXCR4 antagonist. CXCR4 has been implicated in inflammation, cancer, and HIV infection.
Helpful?
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What is the solubility of Product A5602, AMD3100 octahydrochloride hydrate?
1 answer-
AMD3100 octahydrochloride hydrate is soluble in water at 22 mg/ml.
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