A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

• Synonim(y): Ac-QKLVFF-NH₂, amyloid blocker
• Wzór empiryczny (zapis Hilla): C₄₂H₆₃N₉O₈
• Numer CAS: 189064-06-0
• Masa cząsteczkowa: 822.01
• NACRES: NA.32
• PubChem Substance ID: 329770908
• UNSPSC Code: 12352202
• MDL number: MFCD17215285
• Form: powder
• Assay: ≥97% (HPLC)

Właściwości

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: P05067
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
• InChI: 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
• InChI key: DDXTVYDSGCHGAN-PITCCTKHSA-N
• Gene Information: human ... APP(351)

Opis

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)