A7127

Agmatine sulfate salt

≥97% (TLC), powder, ion channel blocker

• Synonim(y): 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt
• Wzór liniowy: H₂N(CH₂)₄NHC(=NH)NH₂·H₂SO₄
• Numer CAS: 2482-00-0
• Masa cząsteczkowa: 228.27
• NACRES: NA.32
• PubChem Substance ID: 24277749
• UNSPSC Code: 12352200
• EC Number: 219-617-3
• MDL number: MFCD00013109
• Beilstein/REAXYS Number: 3918807
• eCl@ss: 32160701
• Assay: ≥97%
• Form: powder

Właściwości

• Nazwa produktu: Agmatine sulfate salt, ≥97%, powder
• Quality Segment: 100
• assay: ≥97%
• form: powder
• color: white to off-white
• mp: 234-238 °C (lit.)
• solubility: H₂O: 50 mg/mL, ethanol: insoluble
• SMILES string: OS(O)(=O)=O.NCCCCNC(N)=N
• InChI: 1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
• InChI key: PTAYFGHRDOMJGC-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Opis

Application

Agmatine sulfate salt has been used:

• to study its effects on nod-like receptor protein 3 (NLRP3) inflammasome activation and cytokine responses in sub-chronic restraint stress rat models
• as an N-methyl-D-aspartate (NMDA) receptor blocker to study its therapeutic effects on autistic behaviors in the valproic acid-induced animal model of autism
• as a standard to determine the bioactive amines in vegetables by high-performance liquid chromatography (HPLC)

Biochem/physiol Actions

Agmatine is a decarboxylated arginine that is present ubiquitously in all living organisms. It is found in food sources such as plant source food and animal products. It exhibits cryoprotective effects against several body functions such as nephroprotection, neuroprotection, gastroprotection, and cardioprotection. Agmatine also exhibits therapeutic effects against neurotrauma, neuropathic pain, diabetes, neurodegenerative diseases, and psychiatric diseases. It is involved in blocking many ionic channels such as ATP-sensitive K⁺ channels and voltage-gated Ca²⁺ channels. Agmatine modulates nitric oxide production and inhibits matrix metalloproteases.

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α₂-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)