A7275

L-2-Aminoadipic acid

≥98% (TLC), powder, glutamine synthetase inhibitor

• Synonim(y): (S)-2-Aminohexanedioic acid, L-Homoglutamic acid, Aad
• Wzór liniowy: HO₂C(CH₂)₃CH(NH₂)CO₂H
• Numer CAS: 1118-90-7
• Masa cząsteczkowa: 161.16
• NACRES: NA.32
• PubChem Substance ID: 24278234
• UNSPSC Code: 12352209
• MDL number: MFCD00002636
• Beilstein/REAXYS Number: 1724348
• Assay: ≥98% (TLC)
• Form: powder

Właściwości

• Nazwa produktu: L-2-Aminoadipic acid, ≥98% (TLC)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 203-205 °C (dec.) (lit.)
• SMILES string: N[C@@H](CCCC(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
• InChI key: OYIFNHCXNCRBQI-BYPYZUCNSA-N
• Gene Information: human ... GLUL(2752), LGSN(51557) ; rat ... Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Grm6(24419)

Opis

General description

L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.

Application

L-2-Aminoadipic acid has been used as a gliotoxin specific for astrocytes in rat. It has also been as an internal standard in the amino acid analysis from fermented food sample.

Biochem/physiol Actions

L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)