A7736

Albumin human

recombinant, expressed in Pichia pastoris, lyophilized powder, ≥90% (agarose gel electrophoresis)

• Synonim(y): Albagen^™, rHSA
• Wzór empiryczny (zapis Hilla): C₂₉₃₆H₄₆₂₄N₇₈₆O₈₈₉S₄₁
• Numer CAS: 70024-90-7
• Masa cząsteczkowa: 66471.53
• UNSPSC Code: 12352202
• NACRES: NA.25
• EC Number: 274-272-6
• MDL number: MFCD00081418
• eCl@ss: 42010201
• Biological source: human
• Assay: ≥90% (agarose gel electrophoresis)
• Form: lyophilized powder
• Technique(s): cell culture | mammalian: suitable

Właściwości

• biological source: human
• Quality Segment: 300
• recombinant: expressed in Pichia pastoris
• assay: ≥90% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer ~67 kDa
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Opis

General description

Construct with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin confirmed x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by eliminating the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Also blocked at Cys³⁴ to improve stability, monomer content and homogeneity.

Application

This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

Biochem/physiol Actions

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

Other Notes

View more information on human serum albumin.

Legal Information

Albagen is a trademark of Albumin Therapeutics, LLC.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable