Product No. A9978, AICAR, is a powder. The color of the powder will be described on the lot specific Certificate of Analysis.
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A9978
AICAR
≥98% (HPLC), powder, AMPK activator
Synonim(y):
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 512,00 zł |
25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1710,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C9H14N4O5
Numer CAS:
Masa cząsteczkowa:
258.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-097-5
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
512,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
AICAR, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
tan
mp
214-215 °C
solubility
H2O: >7 mg/mL
shipped in
dry ice
storage temp.
−20°C
SMILES string
NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
InChI
1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChI key
RTRQQBHATOEIAF-UUOKFMHZSA-N
General description
Adenosine monophosphate protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy. It regulates lipid and glucose metabolism, pro-inflammatory responses, cytokine production, cell proliferation and apoptosis. AICAR improves ischemia or reperfusion injury and kidney fibrosis in rats. It provides protection against acute tubular necrosis.
Application
AICAR has been used to provide protection against cisplatin-induced acute kidney injury through the JAK (tyrosine-protein kinase )/STAT (signal transducer and activator of transcription )/SOCS (suppressor of cytokine signaling) pathway. It also has been used in the assay of FapR (malonyl-CoA responsive bacterial transcriptional factor )-NLuc (nanoLuciferase) biosensor activity.
Biochem/physiol Actions
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK).
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Ta pozycja | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis. | description ≥93% | description ≥95% (HPLC), from synthetic, solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥93% | assay ≥95% (HPLC) |
| form powder | form solid | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: >7 mg/mL | solubility water: soluble, methanol: 10 mg/mL | solubility - | solubility - |
| color tan | color white to brown | color - | color white to beige |
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Klasa składowania
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What is the appearance of Product A9978, AICAR?
1 answer-
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How can I store a solution of AICAR, Product A9978?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to solubilize AICAR, Product A9978?
1 answer-
We list the solubility in water on the lot specific Certificate of Analysis. We typically test the solubility of AICAR in water (7 mg/mL).
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