C1335

S-(−)-Carbidopa

≥98% (TLC), powder

• Synonim(y): (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
• Wzór empiryczny (zapis Hilla): C₁₀H₁₄N₂O₄
• Numer CAS: 28860-95-9
• Masa cząsteczkowa: 226.23
• NACRES: NA.77
• PubChem Substance ID: 24892402
• UNSPSC Code: 12352202
• EC Number: 249-271-9
• MDL number: MFCD00069231
• Assay: ≥98% (TLC)
• Form: powder

Właściwości

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
• InChI: 1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• InChI key: TZFNLOMSOLWIDK-JTQLQIEISA-N
• Gene Information: human ... DDC(1644)

Opis

General description

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Biochem/physiol Actions

Peripheral inhibitor of L-aromatic amino acid decarboxylase.

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H₂O₂ in these cell lines, which are sensitive to reactive oxygen species.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)