C171

Clozapine

solid

• Synonim(y): 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
• Wzór empiryczny (zapis Hilla): C₁₈H₁₉ClN₄
• Numer CAS: 5786-21-0
• Masa cząsteczkowa: 326.82
• UNSPSC Code: 41116107
• PubChem Substance ID: 329774905
• EC Number: 227-313-7
• MDL number: MFCD00153785

Właściwości

• form: solid
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• color: pale yellow
• solubility: ethanol: 11 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL
• format: neat
• SMILES string: CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), HTR2A(3356)

Opis

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Atypical neuroleptic agent which displays greater affinity for the D₄ dopamine receptor over D₂ or D₃ dopamine receptors; displays antipsychotic efficacy against positive and negative symptoms of schizophrenia in patients who do not respond to typical neuroleptics.

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