C271

CX546

≥98% (HPLC), solid

• Synonim(y): 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
• Wzór empiryczny (zapis Hilla): C₁₄H₁₇NO₃
• Numer CAS: 215923-54-9
• Masa cząsteczkowa: 247.29
• NACRES: NA.77
• PubChem Substance ID: 24277960
• UNSPSC Code: 12352200
• MDL number: MFCD01860868
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(N1CCCCC1)c2ccc3OCCOc3c2
• InChI: 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
• InChI key: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Opis

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Biochem/physiol Actions

Positive AMPA glutamate receptor modulator.

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Disclaimer

Photosensitive

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)