This product has been tested for solubility in chloroform at concentrations up to 100 mg/mL. For cell culture applications, it has been reported to dissolve in ethanol at 5 mg/mL (Ke et al., 2020). Based on this data, ethanol should also fully dissolve this product at 10 mM (~3.87 mg/mL).
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C3045
Cholesterol
powder, BioReagent, suitable for cell culture, ≥99%
Synonim(y):
3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 583,00 zł |
25 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2560,00 zł |
100 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 6860,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C27H46O
Numer CAS:
Masa cząsteczkowa:
386.65
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
39023139
UNSPSC Code:
12352211
EC Number:
200-353-2
MDL number:
Beilstein/REAXYS Number:
1915888
583,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
ovine wool
Quality Segment
product line
BioReagent
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
bp
360 °C (lit.)
mp
147-149 °C (lit.)
solubility
H2O: 0.002 mg/mL, Tween: soluble, ethanol: soluble, serum: soluble
density
1.067 g/mL at 25 °C (lit.)
shipped in
ambient
storage temp.
−20°C
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Information
human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)
General description
Listen to an Audio Overview
Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.
Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.
Application
Cholesterol has been used:
- as a medium supplement in chorionic villous tissue culture form placenta
- as a component of hormone pellet for implantation in mice ovary
- for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1
Biochem/physiol Actions
Major component of all biological membranes; ~25% of total brain lipid is cholesterol.
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Ta pozycja | |||
|---|---|---|---|
| description powder, BioReagent, suitable for cell culture, ≥99% | description Sigma Grade, ≥99% | description tested according to Ph. Eur. | description NIST® SRM® 911c |
| assay ≥99% | assay ≥99% | assay - | assay - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| biological source ovine wool | biological source sheep wool | biological source - | biological source - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| shipped in ambient | shipped in ambient | shipped in - | shipped in - |
| form powder | form powder | form powder | form - |
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Klasa składowania
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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How to prepare the BioReagent product, suitable for cell culture, ≥99% for cell culture? For example, I need 10mm/L of disintegrated cholesterol for an experiment. How can I dissolve it? In heated alcohol? Do you have a protocol for using cells?
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