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C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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Rozmiar/SKUDostępnośćCena netto
0.25 unit
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780,00 zł

Informacje o tej pozycji

Numer CAS:
107200-92-0
Numer WE:
3.4.21.20 (BRENDA, IUBMB)
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD00130750
Specific activity:
≥60 units/mg protein (Bradford)
Biological source:
human leucocytes

780,00 zł

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biological source

human leucocytes

Quality Segment

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
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Ta pozycja
C8571C8696C0150
Cathepsin G from human leukocytes lyophilized powder, ≥60 units/mg protein (Bradford)

Sigma-Aldrich

C4428

Cathepsin G from human leukocytes

Cathepsin B from human liver buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

Sigma-Aldrich

C8571

Cathepsin B from human liver

Cathepsin D from human liver lyophilized powder, ≥250 units/mg protein (E1%/280)

Sigma-Aldrich

C8696

Cathepsin D from human liver

Cathepsin B from human placenta lyophilized powder, ≥5 units/mg protein

Sigma-Aldrich

C0150

Cathepsin B from human placenta

description

lyophilized powder, ≥60 units/mg protein (Bradford)

description

buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

description

lyophilized powder, ≥250 units/mg protein (E1%/280)

description

lyophilized powder, ≥5 units/mg protein

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSB(1508)

Gene Information

human ... CTSD(1509)

Gene Information

human ... CTSB(1508)

biological source

human leucocytes

biological source

human liver

biological source

-

biological source

-

specific activity

≥60 units/mg protein (Bradford)

specific activity

≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

specific activity

≥250 units/mg protein (E1%/280)

specific activity

≥5 units/mg protein

form

lyophilized powder

form

buffered aqueous solution

form

lyophilized powder

form

lyophilized powder

mol wt

23-30 kDa

mol wt

-

mol wt

~45 kDa

mol wt

24.5 kDa

UniProt accession no.

P08311

UniProt accession no.

P07858

UniProt accession no.

P07339

UniProt accession no.

P07858

Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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    Certyfikaty analizy (CoA)

    Lot/Batch Number
    013H9453
    SLCQ4000
    SLBP3460V
    SLBD5704
    SLCF4556

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