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C4428

Cathepsin G from human leukocytes

Name: Cathepsin G from human leukocytes
Brand: SIGMA

lyophilized powder, ≥60 units/mg protein (Bradford)

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Informacje o tej pozycji

Numer CAS:

107200-92-0

Numer WE:

3.4.21.20 (BRENDA, IUBMB)

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00130750

Specific activity:

≥60 units/mg protein (Bradford)

Biological source:

human leucocytes

Pomoc techniczna

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Pozwól nam pomóc

Właściwości

biological source

human leucocytes

Quality Segment

200

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

P08311

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

Opis

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

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Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)