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C5688
Complement factor D from human plasma
90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
10 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1700,00 zł 1445,00 zł |
Informacje o tej pozycji
Form:
liquid
Assay:
≥90% (SDS-PAGE)
Biological source:
human plasma
1445,00 zł
Cena katalogowa1700,00 złZaoszczędź 15%Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócApplication
Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.
Biochem/physiol Actions
Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.
Analysis Note
Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Ta pozycja | |||
|---|---|---|---|
| description 90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE) | description ≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein | description ≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein | description >90% (SDS-PAGE) |
| assay ≥90% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay >90% (SDS-PAGE) |
| biological source human plasma | biological source human serum | biological source human serum | biological source human plasma |
| concentration 90-110 μg/mL in PBS, pH 7.2 | concentration 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration 0.95-1.20 mg/mL |
| form liquid | form solution | form solution | form solution |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Klasa składowania
10 - Combustible liquids
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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