Merck
Wszystkie zdjęcia(1)

C5723

Sigma-Aldrich

Anti-Cytochrome c antibody produced in sheep

whole antiserum

Numer MDL:
NACRES:
NA.41

Poziom jakości

200

pochodzenie biologiczne

sheep

białko sprzężone

unconjugated

forma przeciwciała

whole antiserum

antibody product type

primary antibodies

klon

polyclonal

masa cząsteczkowa

antigen 14.4 kDa

species reactivity

human, rabbit, rat, canine

technique(s)

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 1:5,000 using MCF-7, Rat-1, MDCK or Jurkat cell extracts

numer dostępu UniProt

transport

dry ice

temp. przechowywania

−20°C

Gene Information

human ... CYCS(54205)
rat ... Cycs(25309)

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Immunogen

rabbit cytochrome c

Zastosowanie

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Opis wartości docelowych

Cytochrome c is an electron transport protein released from mitochondria as an early committed event in apoptosis. Cytochrome c and dATP are cofactors for the mammalian apoptosome, which is composed of Apaf-1, Bcl-2, and procaspase 9. When caspase 9 is activated, activation of other caspases follow including the death protease caspase 3. The release of cytochrome c is inhibited by the presence of Bcl-2 on these organelles preventing the initiation of apoptosis. In cells induced by several apoptotic agents (such as UV irradiation, staurosporine, and overexpression of Bax), caspase inhibitors do not prevent cytochrome c release.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Kod klasy składowania

12 - Non Combustible Liquids

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Certyfikat analizy

Wprowadź numer partii, aby wyszukać certyfikat analizy (COA).

Świadectwo pochodzenia

Wprowadź numer partii, aby wyszukać świadectwo pochodzenia (COO).

Debolina Ghosh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5821-5832 (2012-04-28)
The brain depends on redox electrons from nicotinamide adenine dinucleotide (reduced form; NADH) to produce ATP and oxyradicals (reactive oxygen species [ROS]). Because ROS damage and mitochondrial dysregulation are prominent in aging and Alzheimer's disease (AD) and their relationship to
Merrick S Reynolds et al.
American journal of physiology. Endocrinology and metabolism, 311(1), E186-E201 (2016-05-26)
β-Cell insulin secretion is dependent on proper mitochondrial function. Various studies have clearly shown that the Nr4a family of orphan nuclear receptors is essential for fuel utilization and mitochondrial function in liver, muscle, and adipose. Previously, we have demonstrated that
John F Merrill et al.
Nutrition & metabolism, 9(1), 104-104 (2012-11-23)
As a cellular energy sensor, the 5'AMP-activated protein kinase (AMPK) is activated in response to energy stresses such as hypoxia and muscle contraction. To determine effects of iron deficiency on AMPK activation and signaling, as well as the AMPK subunit
M G Vander Heiden et al.
Cell, 91(5), 627-637 (1997-12-11)
Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a wide variety of apoptotic and necrotic stimuli induce progressive mitochondrial swelling and outer mitochondrial membrane rupture. Discontinuity of the outer mitochondrial membrane results in cytochrome c
E Bossy-Wetzel et al.
The EMBO journal, 17(1), 37-49 (1998-02-28)
Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells undergoing apoptosis, where it participates in the activation of DEVD-specific caspases. The apoptosis inhibitors Bcl-2 or Bcl-xL prevent the efflux of

Produkty

Electron Transport

Learn about the four membrane-bound protein complexes that make up the electron transport chain metabolic pathway supplying energy as ATP for cellular respiration.

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