D1634

Diosgenin

≥93%, apoptosis inducer, powder

• Synonim(y): (25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene, Nitogenin
• Wzór empiryczny (zapis Hilla): C₂₇H₄₂O₃
• Numer CAS: 512-04-9
• Masa cząsteczkowa: 414.62
• NACRES: NA.77
• PubChem Substance ID: 24893501
• UNSPSC Code: 12352200
• EC Number: 208-134-3
• MDL number: MFCD00016887
• Beilstein/REAXYS Number: 94582
• Assay: ≥93%
• Form: powder

Właściwości

• Nazwa produktu: Diosgenin, ≥93%
• Quality Segment: 200
• assay: ≥93%
• form: powder
• SMILES string: [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2
• InChI: 1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
• InChI key: WQLVFSAGQJTQCK-VKROHFNGSA-N
• Gene Information: human ... UGT1A4(54657)

Opis

General description

Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.

Application

Diosgenin has been:

• used as a standard in the analysis of total saponins in Sapindus rarak
• orally administered to the rats to study its role against atherogenic diet-induced production of inflammatory mediators in heart, liver and brain
• used as a standard compound to determine the saponins content in chickpea and Tribulus terrestris

Biochem/physiol Actions

Diosgenin induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and cyclooxygenase activity in osteosarcoma cells. It serves as a precursor in steroid drug production. Diosgenin is shown to promote cholesterol production by stimulating biliary excretion. It influences lipoxygenase induced human erythroleukemia cell line differentiation.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)