E6657

Eplerenone

≥98% (HPLC), aldosterone blocker, powder

• Synonim(y): 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110
• Wzór empiryczny (zapis Hilla): C₂₄H₃₀O₆
• Numer CAS: 107724-20-9
• Masa cząsteczkowa: 414.49
• MDL number: MFCD05662207
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798999
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Eplerenone, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed), H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C
• InChI: 1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
• InChI key: JUKPWJGBANNWMW-VWBFHTRKSA-N
• Gene Information: human ... NR3C2(4306)

Opis

General description

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.

Application

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.

Biochem/physiol Actions

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.

Eplerenone is an aldosterone antagonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)