M2070

Merbarone

≥98% (HPLC), solid

• Synonim(y): 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
• Wzór empiryczny (zapis Hilla): C₁₁H₉N₃O₃S
• Numer CAS: 97534-21-9
• Masa cząsteczkowa: 263.27
• NACRES: NA.77
• PubChem Substance ID: 24724534
• UNSPSC Code: 12352200
• MDL number: MFCD00866337
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
• InChI: 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
• InChI key: JARCFMKMOFFIGZ-UHFFFAOYSA-N

Opis

Application

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Biochem/physiol Actions

Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.

Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)