M3172

Mitogen activated protein kinase from rat

≥95% (SDS-PAGE), buffered aqueous glycerol solution, recombinant, expressed in E. coli (N-terminal histidine tagged)

• Synonim(y): ERK2, Extracellular-signal regulated kinase, MAP Kinase Activated from rat, MAPK
• UNSPSC Code: 12352200
• MDL number: MFCD00677284

Właściwości

• recombinant: expressed in E. coli (N-terminal histidine tagged)
• assay: ≥95% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: ≥500 U/mg
• mol wt: 42 kDa
• UniProt accession no.: P63086
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: rat ... Mapk1(116590)

Opis

Biochem/physiol Actions

MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade. The cascade starts with extracellular signals transmitted by growth factor-regulated receptor tyrosine kinases or G-protein coupled receptors. Dually phosphorylated (Thr and Tyr) MAP kinase translocates from the cytoplasm to the nucleus, where it phosphorylates protein transcription factors, transducing extracellular signals into genomic responses, proliferation or differentiation.

MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade.

Physical form

Solution in 20 mM Tris, pH 7.5, 150 mM NaCl, 1 mM EGTA, 10% glycerol, 1 mM DTT, and 0.03% Brij^®.

Other Notes

One unit of activated MAP kinase will transfer 1 nmole of phosphate from ATP to myelin basic protein per min at 30 °C.

Legal Information

Brij is a registered trademark of Croda International PLC

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable