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MTOX1303
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells
canine kidney (cocker spaniel)
Synonim(y):
MDCKII hMDR1 knockin cells
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Informacje o tej pozycji
UNSPSC Code:
12352207
NACRES:
NA.81
Biological source:
canine kidney (cocker spaniel)
Informacje o cenach i dostępności nie są obecnie dostępne.
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells,
biological source
canine kidney (cocker spaniel)
Quality Segment
form
liquid
storage temp.
−196°C
Gene Information
human ... ABCB1(5243)
Application
See technical bulletin for detailed protocols
Features and Benefits
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.
The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human MDR1 (P-gp) has been transfected into the MDCKII cell line. Validation studies have shown efflux of standard MDR1 substrates.
Analysis Note
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.
Legal Information
This product is covered under a consumable purchase agreement for one-time use only. For more information:ADME/Tox Cell Lines LicenseMDCKII subclone was originally isolated by Daniel Louvard, Institut Curie, Paris France.
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Ta pozycja | |||
|---|---|---|---|
| description - | description - | description - | description 1 vial |
| biological source canine kidney (cocker spaniel) | biological source canine kidney (cocker spaniel) | biological source canine kidney (cocker spaniel) | biological source human female liver (Source Disease: Hepatocarcinoma and Hepatitis C) |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| Gene Information human ... ABCB1(5243) | Gene Information human ... ABCG2(9429) | Gene Information - | Gene Information human ... ABCB1(5243) |
| form liquid | form liquid | form liquid | form liquid |
Klasa składowania
10 - Combustible liquids
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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