N2255

S-(4-Nitrobenzyl)-6-thioinosine

≥98%, Adenosine uptake inhibitor, solid

• Synonim(y): 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine, NBMPR, NBTI
• Wzór empiryczny (zapis Hilla): C₁₇H₁₇N₅O₆S
• Numer CAS: 38048-32-7
• Masa cząsteczkowa: 419.41
• NACRES: NA.77
• PubChem Substance ID: 24277723
• UNSPSC Code: 12352202
• EC Number: 253-753-4
• MDL number: MFCD00005745
• Assay: ≥98%
• Form: solid

Właściwości

• Nazwa produktu: S-(4-Nitrobenzyl)-6-thioinosine, ≥98%, solid
• Quality Segment: 100
• assay: ≥98%
• form: solid
• color: white
• mp: 187-190 °C (lit.)
• solubility: 0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(SCc4ccc(cc4)[N+]([O-])=O)ncnc23
• InChI: 1S/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1
• InChI key: DYCJFJRCWPVDHY-LSCFUAHRSA-N
• Gene Information: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), SLC29A1(2030)

Opis

General description

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biochem/physiol Actions

Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

Potent adenosine uptake inhibitor

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)