O8757

Ofloxacin

fluoroquinolone antibiotic

• Synonim(y): Dextrofloxacin
• Wzór empiryczny (zapis Hilla): C₁₈H₂₀FN₃O₄
• Numer CAS: 82419-36-1
• Masa cząsteczkowa: 361.37
• UNSPSC Code: 51282956
• PubChem Substance ID: 24278613
• NACRES: NA.76
• MDL number: MFCD00226105

Właściwości

• biological source: synthetic
• Quality Segment: 200
• form: powder
• solubility: 1 M NaOH: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: FC1=C(C3=[c]4[n](cc([c]([c]4=C1)=O)C(=O)O)C(CO3)C)N2CCN(CC2)C
• InChI: 1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
• InChI key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N
• Gene Information: human ... CSNK2A1(1457), KCNH1(3756) ; rat ... Gabra1(29705)

Opis

General description

Chemical structure: fluoroquinolone

Application

Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery.

Biochem/physiol Actions

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)