P0043

PNU-120596

≥98% (HPLC)

• Synonim(y): N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea, NSC 216666
• Wzór empiryczny (zapis Hilla): C₁₃H₁₄ClN₃O₄
• Numer CAS: 501925-31-1
• Masa cząsteczkowa: 311.72
• NACRES: NA.77
• PubChem Substance ID: 329819995
• UNSPSC Code: 12352200
• MDL number: MFCD00095313
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC
• InChI: 1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
• InChI key: CEIIEALEIHQDBX-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.

PNU-120596 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable