P0108

PRL-3 Inhibitor I

≥98% (HPLC), solid

• Synonim(y): 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone, Phosphatase of regenerating liver-3, Inhibitor I
• Wzór empiryczny (zapis Hilla): C₁₇H₁₁Br₂NO₂S₂
• Numer CAS: 893449-38-2
• Masa cząsteczkowa: 485.21
• NACRES: NA.77
• PubChem Substance ID: 329820016
• UNSPSC Code: 12352200
• MDL number: MFCD11045303
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: yellow
• solubility: DMSO: >10 mg/mL, H₂O: <2 mg/mL
• storage temp.: −20°C
• SMILES string: Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O
• InChI: 1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
• InChI key: HXNBAOLVPAWYLT-OVCLIPMQSA-N

Opis

Application

PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):

• to test its effect on classical Hodgkin lymphoma cell survival
• in the human umbilical vein endothelial cells tube formation assay
• to test its effect on the migration of neural crest cells

Biochem/physiol Actions

PRL-3 Inhibitor I is a rhodanine derivative with an IC₅₀ value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves