The concentration can be confirmed on the Certificate of Analysis that's specific to the lot you received, found here:https://www.sigmaaldrich.com/US/en/product/sigma/p2980#product-documentation
As of April 2024, the current specification is 0.2mg/mL
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P2980
Pertussis toxin
from Bordetella pertussis, buffered aqueous glycerol solution, protein endotoxin
Synonim(y):
Histamine-sensitizing factor, IAP, Islet Activating Protein, PTX, Pertussigen
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
50 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3530,00 zł |
0.2 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 9960,00 zł |
Informacje o tej pozycji
Form:
buffered aqueous glycerol solution
3530,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Pertussis toxin from Bordetella pertussis, buffered aqueous glycerol solution
description
aseptically packaged
Quality Segment
form
buffered aqueous glycerol solution
shipped in
dry ice
storage temp.
−20°C
SMILES string
O(C)C(=O)CCCCCCCCCCCCCCCCCCCCCCCC
InChI
1S/C26H52O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28-2/h3-25H2,1-2H3
InChI key
WOPKHAQDUMDJIY-UHFFFAOYSA-N
Gene Information
Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)
General description
Pertussis (Pertussis) toxin (PTX) is a protein isolated from the bacterium Bordatella (Bordatella) coccobaccillus. The toxin is excreted in a non-active state. When the B oligomer of the bacterium, Bordatella coccobacillus, comes in contact with the cell membrane, an S1 subunit of its A protomer is activated. This activation may be mediated by glutathione and/or ATP.
Application
Pertussis toxin from Bordetella pertussis has been used: to enhance cardiac myosin immunization of rats to induce myocarditis; to break down the blood–brain barrier in the Cuprizone and cuprizone/MOG-EAE model; as an inhibitor of Gαi signaling
Inactive toxin form released from B. pertussis.
The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.
Biochem/physiol Actions
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt.
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Physical form
Aseptically filled solution in 50% glycerol, containing 50 mM TRIS, 10 mM glycine, 0.5 M NaCl, pH 7.5
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Ta pozycja | |||
|---|---|---|---|
| description buffered aqueous glycerol solution | description lyophilized powder | description This Pertussis toxin, CAS 70323-44-3, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt. | description Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. |
| form buffered aqueous glycerol solution | form lyophilized powder | form lyophilized | form liquid |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| shipped in dry ice | shipped in - | shipped in ambient | shipped in wet ice |
| Gene Information Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408) | Gene Information Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408) | Gene Information - | Gene Information - |
| description aseptically packaged | description - | description RTECS - XW5883750 | description RTECS - XW5883750 |
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Klasa składowania
10 - Combustible liquids
Co się dzieje?
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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We purchased the 50 uG size of the P2980 Pertussis Toxin. I am unable to find what the volume of solution in the container is to calculate uG/mL concentration.
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