P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

• Synonim(y): PAβN
• Wzór empiryczny (zapis Hilla): C₂₅H₃₀N₆O₂ · 2HCl
• Numer CAS: 100929-99-5
• Masa cząsteczkowa: 519.47
• UNSPSC Code: 12352204
• PubChem Substance ID: 24898508
• NACRES: NA.32
• MDL number: MFCD00058046

Właściwości

• Nazwa produktu: Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
• InChI key: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

Opis

General description

Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)