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P7936

Phosphocreatine disodium salt hydrate

≥97%

Synonim(y):

Creatine phosphate disodium salt, N-(Imino[phosphonoamino]methyl)-N-methylglycine

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Rozmiar/SKUDostępnośćCena netto
10 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
231,00 zł
1 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
569,00 zł
5 g
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1250,00 zł
25 g
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3940,00 zł

Informacje o tej pozycji

Wzór liniowy:
C4H8N3O5PNa2 · x H2O
Numer CAS:
Masa cząsteczkowa:
255.08 (anhydrous basis)
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
213-074-6
MDL number:

231,00 zł


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Nazwa produktu

Phosphocreatine disodium salt hydrate, ≥97%

Quality Segment

assay

≥97%

form

powder

impurities

≤0.02% free creatine

color

white

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O

InChI

1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2

InChI key

KZVYPOKBYRXZKS-UHFFFAOYSA-L

Application

Phosphocreatine disodium salt hydrate has been used:
  • as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins
  • of M5+ buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments
  • of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay

Biochem/physiol Actions

Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells.
Phosphocreatine disodium salt hydrate is useful to study nasopharyngeal carcinoma cells and induced temporary cardiac arrest. It also evaluate the effects of adenosine A(2A) receptor modulation in the nucleus accumbens on cocaine seeking in rats.
Phosphocreatine, a high-energy phosphate reservoir in vertebrate and some invertebrate muscles, provides phosphate for ADP-ATP conversion.

Preparation Note

Prepared enzymatically
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Ta pozycja
P1937237911C3755
description

≥97%

description

≥95% (enzymatic)

description

A high-energy phosphate compound. Transfer of phosphate group from creatine phosphate to ADP and from ATP to creatine form the basis of the creatine-creatine phosphate energy shuttle.

description

Type I, salt-free, lyophilized powder, ≥150 units/mg protein

form

powder

form

powder

form

solid

form

salt-free, lyophilized powder

assay

≥97%

assay

≥95% (enzymatic)

assay

≥98% (TLC)

assay

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

impurities

≤0.02% free creatine

impurities

-

impurities

-

impurities

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 5 mg/mL

solubility

0.25 M glycyl-glycine, pH 7.4: soluble 5.0 mg/mL, clear, colorless to slightly yellow


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Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

PPE (środki ochrony indywidualnej)

Eyeshields, Gloves, type N95 (US)



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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How to calulate the concentration(M) of this product? Because the Linear Formula is 4H8N3O5PNa2 · x H2O, it could not be calculted real molecular weight.

    1 answer
    1. The exact molar mass of this product is lot-specific but can be estimated using the reported water content determined by Karl Fischer analysis. The specification for water content is set between 22% and 28% as a weight percentage. For detailed assistance with determining degrees of hydration from reported water content, local Technical Service should be contacted directly.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  4. Va bene come Fosfocreatina?

    1 answer
    1. The sodium form of phosphocreatine, in equimolar quantities, is comparable to the free form in biological activity. The sodium form demonstrates a higher solubility rate in water. Certain applications may require a specific form, which would have to be determined by the end user.

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