S0577

Streptokinase C from Streptococcus sp.

lyophilized solid, ≥3,500 unit/mg solid

• Synonim(y): Streptokinase
• UNSPSC Code: 12352204
• NACRES: NA.54
• Numer WE: 3.4.99.0 (BRENDA, IUBMB)
• Specific activity: ≥3,500 unit/mg solid
• Assay: 40—60% protein (biuret)
• Biological source: bacterial (Streptococcus sp.)
• Recombinant: expressed in E. coli

Właściwości

• biological source: bacterial (Streptococcus sp.)
• Quality Segment: 200
• recombinant: expressed in E. coli
• assay: 40—60% protein (biuret)
• form: lyophilized solid
• specific activity: ≥3,500 unit/mg solid
• color: off-white to light yellow
• application(s): life science and biopharma
• storage temp.: −20°C
• Gene Information: Streptococcus pyogenes ... SKC(134997)

Opis

General description

Research area: Cell Signaling

Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.

Application

Streptokinase C from Streptococcus sp. has been used to quantitate the survival of Staphylococcus aureus in whole human blood.

Biochem/physiol Actions

Streptokinase shows fibrinolytic activity by triggering the circulatory plasminogen either via a fibrin-dependent or fibrin-independent mechanism. Streptokinase has been studied majorly in terms of its therapeutic efficacy and treating myocardial infarction to dissolve clots.

Physical form

Lyophilized powder containing approx. 50% bovine serum albumin (total protein by biuret) with sodium glutamate.

Other Notes

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable