S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

• Synonim(y): α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
• Wzór empiryczny (zapis Hilla): C₁₆H₁₂F₃N₃S
• Numer CAS: 305350-87-2
• Masa cząsteczkowa: 335.35
• NACRES: NA.77
• PubChem Substance ID: 329824537
• UNSPSC Code: 12352200
• MDL number: MFCD06411432
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light
• color: white to off-white
• mp: 127-128.2 °C
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
• InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• InChI key: JLOXTZFYJNCPIS-FYWRMAATSA-N

Opis

Application

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)