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SCP0004

γ Secretase Inhibitor

≥95% (HPLC)

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Rozmiar/SKUDostępnośćCena netto
5 mg
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1250,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C26H41N3O5
Masa cząsteczkowa:
475.62
NACRES:
NA.32
UNSPSC Code:
12352200

1250,00 zł

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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

General description

Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.

Application

γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.
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Ta pozycja
SCP0025565750565773
γ Secretase Inhibitor ≥95% (HPLC)

Sigma-Aldrich

SCP0004

γ Secretase Inhibitor

APP γ Secretase Inhibitor

Sigma-Aldrich

SCP0025

APP γ Secretase Inhibitor

Inhibitor γ-sekretazy I The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565750

Inhibitor γ-sekretazy I

γ-Secretase Inhibitor XII The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Sigma-Aldrich

565773

γ-Secretase Inhibitor XII

description

≥95% (HPLC)

description

-

description

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

description

The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

form

lyophilized

form

solid

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

desiccated (hygroscopic), OK to freeze

storage condition

protect from light, OK to freeze

composition

Peptide Content, ≥85%

composition

Peptide Content, ≥75%

composition

-

composition

-

Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

  1. What are the reconstitution instructions for this compound? I checked the SDS, COA, and spec sheet. Also what is the CAS#?

    1 answer

    1. The solubility of this product is in DMSO at 1 mg/ml or higher.

      In biological experiments, water is the most preferred solvent. However, several organic compounds are either not soluble in water or degrade rapidly in the presence of moisture. If DMSO is a recommended solvent, it is best to use a fresh stock bottle that is deemed free of any moisture. Any contaminating moisture may accelerate the degradation of the compound in question or may render it insoluble. It is best to make the initial serial dilutions only in DMSO and then add the final diluted sample to your buffer or the incubation medium. The final concentration of DMSO in vivo should not exceed more than 0.1 %.

      Please see the general information about the use of inhibitors in animals and these data sheets from other γ-Secretase Inhibitors from Calbiochem, which may be useful:
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-I-Calbiochem,EMD_BIO-565750#anchor_PDS
      http://www.emdmillipore.com/product/-Secretase-Inhibitor-XX-CAS-209984-56-5-Calbiochem,EMD_BIO-565789#anchor_PDS

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