SML0059

BLT-1

≥98% (HPLC)

• Synonim(y): 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
• Wzór empiryczny (zapis Hilla): C₁₂H₂₃N₃S
• Numer CAS: 321673-30-7
• Masa cząsteczkowa: 241.40
• NACRES: NA.77
• PubChem Substance ID: 329825125
• UNSPSC Code: 51111800
• MDL number: MFCD00571007
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥13 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCCCCCC1CCC\C1=N/NC(N)=S
• InChI: 1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
• InChI key: OWGUSBISUVLUJF-SDNWHVSQSA-N

Opis

Application

BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.

Biochem/physiol Actions

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable