SML0374

U-104

≥98% (HPLC)

• Synonim(y): 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• Wzór empiryczny (zapis Hilla): C₁₃H₁₂FN₃O₃S
• Numer CAS: 178606-66-1
• Masa cząsteczkowa: 309.32
• NACRES: NA.77
• PubChem Substance ID: 329825375
• UNSPSC Code: 12352200
• MDL number: MFCD00159265
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >15 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

U-104 is a carbonic anhydrase IX (CAIX) inhibitor and a CAXII inhibitor.

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable