SML0413

FQI1

≥98% (HPLC)

• Synonim(y): 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
• Wzór empiryczny (zapis Hilla): C₁₈H₁₇NO₄
• Numer CAS: 599151-35-6
• Masa cząsteczkowa: 311.33
• NACRES: NA.77
• PubChem Substance ID: 329825408
• UNSPSC Code: 12352200
• MDL number: MFCD03632583
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1
• InChI: 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
• InChI key: YKSYGLXHLSPWLB-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.

FQI1 is an inhibitor of transcription factor LSF.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3