SML0522

JM6

≥97% (HPLC)

• Synonim(y): 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide
• Wzór empiryczny (zapis Hilla): C₂₃H₂₆N₄O₆S₂
• Numer CAS: 1008119-83-2
• Masa cząsteczkowa: 518.61
• NACRES: NA.77
• PubChem Substance ID: 329825529
• UNSPSC Code: 12352200
• MDL number: MFCD22380618
• Assay: ≥97% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL (clear solution, warmed)
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1OC)S(=O)(=O)Nc2nc(c(CN3CCCCC3)s2)-c4cccc(c4)[N+]([O-])=O
• InChI: 1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
• InChI key: AOZLMMDVJOGGEQ-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease.

JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO); Ro 61-8048 analog.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable