SML1064

IMM-01

≥98% (HPLC)

• Synonim(y): 2-[(2,4-Dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-hydrazinecarbothioamide, Intramimic-01, N1-(tert-Butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide
• Wzór empiryczny (zapis Hilla): C₁₂H₁₇N₃O₂S
• Numer CAS: 218795-74-5
• Masa cząsteczkowa: 267.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S=C(N\N=C\c1c(cc(cc1)O)O)NC(C)(C)C
• InChI: 1S/C12H17N3O2S/c1-12(2,3)14-11(18)15-13-7-8-4-5-9(16)6-10(8)17/h4-7,16-17H,1-3H3,(H2,14,15,18)/b13-7+
• InChI key: LTFUAYRGVLQXKC-NTUHNPAUSA-N

Opis

Application

IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs).

Biochem/physiol Actions

IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.

IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly.

IMM-01 binds and activates formin thereby leading to autoinhinition.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable