SML1464

SMBA1

≥98% (HPLC)

• Synonim(y): 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol, 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
• Wzór empiryczny (zapis Hilla): C₂₀H₁₃NO₃
• Numer CAS: 906440-37-7
• Masa cząsteczkowa: 315.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825898
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C\2C=C([N+]([O-])=O)C=C4
• InChI: 1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
• InChI key: PEYKRJBXACUOOB-WOJGMQOQSA-N

Opis

Biochem/physiol Actions

SMBA1 is a potent and selective Bax agonist.

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable