SML1552

Tipiracil hydrochloride

≥98% (HPLC), thymidine phosphorylase inhibitor, powder

• Synonim(y): 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride
• Wzór empiryczny (zapis Hilla): C₉H₁₁ClN₄O₂ · HCl
• Numer CAS: 183204-72-0
• Masa cząsteczkowa: 279.12
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825960
• NACRES: NA.77
• MDL number: MFCD01571384
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: Tipiracil hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
• InChI: 1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
• InChI key: KGHYQYACJRXCAT-UHFFFAOYSA-N
• Gene Information: human ... TYMP(1890)

Opis

Biochem/physiol Actions

Tipiracil is an inhibitor of thymidine phosphorylase.

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable